UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN
Pengcheng Wang, Ziqiao Wang, Fei Feng, Lisha Yin, Yuyuan Zhang, Zhichao Gao, Jiannan Chen, Ping Zhang, Shuiqiao Yuan, Qiang Ding, Yue Hong, Yuanlin Song, Chun Li, Jincun Zhao, Rong Zhang
This study identifies UHRF1 as a host factor that restricts HCoV-229E infection by epigenetically silencing its receptor APN, with age-related UHRF1 decline linked to increased viral susceptibility.
Nature Communications · Nov 18, 2025Peer-reviewedMicrobiology