Author

Britta A. M. Bouwman

Science for Life LaboratoryORCID 0000-0002-9827-9497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1

Frequent Co-Authors

Nicola CrosettoiD· 3 shared Amin AllahyariD· 1 shared Andrea Abou Yaghi· 1 shared Benjamin D. RowlandiD· 1 shared Carlo VermeuleniD· 1 shared Chi Wai YipiD· 1 shared Colin A M SempleiD· 1 shared Elzo de WitiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersGenomics

Nicola CrosettoORCID

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4 papers

Recent·Most cited

GenomicsbioRxivPreprintMar 13, 2025

Chromatin-associated intronic RNAs from long genes form introsomes that shape nuclear architecture in neuronal cells

Wenjing Kang, Wing Hin Yip, Xiaoze Li-Wang…·Magda Bienko

The paper identifies trans-contacting intronic RNAs (TIRs) in neuronal cells that form nuclear scaffolds called introsomes, influencing 3D genome organization and gene expression.

2 citations

humanbulk RNA-seq

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GeneticsbioRxivPreprintJan 3, 2020

ERCC1-XPF Interacts with Topoisomerase IIβ to Facilitate the Repair of Activity-induced DNA Breaks

Georgia Chatzinikolaou, Kalliopi Stratigi, Kyriacos Agathangelou…·George A. Garinis

The paper shows ERCC1-XPF interacts with TOP IIβ to repair transcription-induced DNA breaks, explaining clinical heterogeneity in related disorders.

1 citation

humanDNA methylation

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BioinformaticsGenome biologyPeer-reviewedFeb 8, 2019

Modelling double strand break susceptibility to interrogate structural variation in cancer

Tracy J. Ballinger, Britta A. M. Bouwman, Reza Mirzazadeh…·Colin A M Semple

The paper develops genome-wide models of DNA double strand break (DSB) susceptibility to identify structural variants (SVs) under positive or purifying selection in cancer.

25 citations

humanwhole-genome sequencing

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GeneticsNature GeneticsPeer-reviewedJul 6, 2018

Locus-Specific Enhancer Hubs And Architectural Loop Collisions Uncovered From Single Allele DNA Topologies

Amin Allahyar, Carlo Vermeulen, Britta A. M. Bouwman…·Wouter L. de Laat

The paper introduces a new 3C method, MC-4C, to study multi-way DNA conformations and reveals cooperative and competitive chromatin interactions, including enhancer hubs and loop collisions.

227 citationstop 1%

Hi-Cexperimental assay

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