Metabolic remodelling in hiPSC-derived myofibres carrying the m.3243A>G mutation
Gabriel E. Valdebenito, Anitta R. Chacko, Chih-Yao Chung, Preethi Sheshadri, Haoyu Chi, Benjamin O’Callaghan, Monika J. Madej, Henry Houlden, Hannah Rouse, Valle Morales, Katiuscia Bianchi, Francesco Saverio Tedesco, Robert D. S. Pitceathly, Michael R. Duchen
This study generates hiPSC-derived myofibres with the m.3243A>G mutation to model mitochondrial disease, showing metabolic and physiological changes related to mutation load.
Stem Cell Reports · Mar 13, 2025Peer-reviewedCell Biology