Katiuscia Bianchi

β3-Integrin controls pericyte metabolic states and shapes tumour-stromal metabolic crosstalk in breast cancer

This study identifies two β3-integrin-dependent metabolic states in pericytes and shows their impact on tumour-stromal metabolic interactions in breast cancer.

Chaperone AIP Couples mTORC1 Activation and Catabolic Metabolism During Neonatal Development

The paper identifies AIP as a regulator that links mTORC1 activation with catabolic metabolism during neonatal development, ensuring metabolic adaptation and survival.

Coenzyme A homeostasis regulates hypoxic signalling via UBFD1in triple-negative breast cancer

This study identifies CoAsy as a regulator of HIF signalling in TNBC, showing its loss stabilizes HIF-1 and HIF-2 and correlates with poor patient outcomes.

Metabolic remodelling in hiPSC-derived myofibres carrying the m.3243A>G mutation

This study generates hiPSC-derived myofibres with the m.3243A>G mutation to model mitochondrial disease, showing metabolic and physiological changes related to mutation load.

Biallelic Loss of Molecular Chaperone Molecule AIP Results in a Novel Severe Multisystem Disease Defined by Defective Proteostasis

This study shows that biallelic AIP loss causes a severe pediatric disease with proteostasis defects, observed in human and zebrafish models.