Valle Morales

This study identifies two β3-integrin-dependent metabolic states in pericytes and shows their impact on tumour-stromal metabolic interactions in breast cancer.

The paper identifies AIP as a regulator that links mTORC1 activation with catabolic metabolism during neonatal development, ensuring metabolic adaptation and survival.

This study identifies CoAsy as a regulator of HIF signalling in TNBC, showing its loss stabilizes HIF-1 and HIF-2 and correlates with poor patient outcomes.

This study generates hiPSC-derived myofibres with the m.3243A>G mutation to model mitochondrial disease, showing metabolic and physiological changes related to mutation load.

This study shows that pyruvate metabolism affects fibroblast response to GLS1 inhibition during fibrosis, suggesting combined targeting of pyruvate metabolism and glutaminolysis as a therapeutic strategy.

This study shows that biallelic AIP loss causes a severe pediatric disease with proteostasis defects, observed in human and zebrafish models.