Francesco Saverio Tedesco

This study identifies NAD+ limitation and α-ketoglutarate depletion as mechanisms by which pancreatic cancer cells induce muscle atrophy through metabolic rewiring and redox imbalance.

This paper develops a human iPSC-based model of L-CMD to test gene editing strategies for muscle laminopathies, showing partial reversal of disease phenotypes with precise mutation correction.

VISIBLE is a system for real-time manipulation and bioprinting of complex in vitro models, enabling precise interventions and improving reproducibility in biomedical research.

This study generates hiPSC-derived myofibres with the m.3243A>G mutation to model mitochondrial disease, showing metabolic and physiological changes related to mutation load.

This study uses CRISPR-Cas9 to disrupt miR binding sites and upregulate utrophin in DMD models, showing functional improvements and therapeutic potential.