Laura van ‘t Veer

The paper identifies ThPOK/ZBTB7B as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype by suppressing metastatic pathways.

The paper develops predictive models using patient-derived breast cancer organoids to identify drug responses and guide new therapies for resistant disease.

The paper evaluates cell lines as models of primary tumors across 22 types using transcriptomic data, finding cell-cycle pathways are consistently upregulated in cell lines.