Jennifer M. Rosenbluth

AutoBlot enables deterministic single-cell western blotting, revealing proteomic diversity in rare cell populations with high occupancy and resolution.

The paper identifies a co-dependency between CDK12 and the BAF chromatin-remodeling complex in TNBC, showing that their co-inhibition synergistically reduces cancer cell viability.

This paper introduces a shape analysis algorithm, LCPC, to quantify spatial morphology and context in 2D and 3D cell cultures, capturing features like chirality that traditional metrics miss.

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

The paper identifies hormone signaling and immune programs as factors determining endocrine responsiveness in breast tissue with background parenchymal enhancement.

EpiBlot maps chromatin accessibility and proteoform expression in HER2-expressing breast cancer cells, revealing distinct epigenetic and protein responses to therapies.

The paper develops predictive models using patient-derived breast cancer organoids to identify drug responses and guide new therapies for resistant disease.

This study shows that fine needle aspiration biopsy (FNAB) effectively harvests cells for patient-derived organoids modeling breast ductal carcinoma in situ, with faster growth times compared to core needle biopsy.