Denise M. Wolf

Characterization of the somatic landscape and transcriptional profile of breast tumors from 748 Hispanic/Latina women in California

The paper analyzes somatic mutations and transcriptional profiles in breast tumors from 748 Hispanic/Latina women, finding differences in tumor immune microenvironment ecotypes linked to ancestry and APOBEC3A/B copy-number deletions.

Organoid-evaluable clinical biomarkers predict drug responses and guide new breast cancer therapies

The paper develops predictive models using patient-derived breast cancer organoids to identify drug responses and guide new therapies for resistant disease.

Comprehensive transcriptomic analysis of cell lines as models of primary tumor samples across 22 tumor types

The paper evaluates cell lines as models of primary tumors across 22 types using transcriptomic data, finding cell-cycle pathways are consistently upregulated in cell lines.