Karine Rizzoti

This study identifies BDNF as a key signal for pituitary stem cell differentiation and homeostasis in mouse models of glucocorticoid deficiency.

The paper shows that microglia use Rank signaling to regulate GnRH function and the HPG axis, leading to hypogonadotropic hypogonadism when disrupted.

The PRKCA D463H mutation, an inactivating kinase mutation, acts as a gain-of-function oncogenic driver in mice, promoting chondrosarcoma through non-catalytic mechanisms.

The paper shows that most gonadotrophs in adults originate from postnatal pituitary stem cells during minipuberty, while embryonic gonadotrophs are maintained, revealing a dual origin.

The paper uses single-cell technologies to study pituitary stem cell heterogeneity and shows that differentiation is more frequent and diverse than previously thought, with maintenance of progeny dependent on the microenvironment.

This study shows that neural plate progenitors contribute to both anterior and posterior pituitary cells in zebrafish and mouse, challenging the traditional view of pituitary cell origins.

This study shows that Sox3 absence causes hypopituitarism by affecting median eminence NG2-glia, which can be rescued by aspirin or gut microbiota changes.

The paper shows that SOX9 is essential for dentate gyrus development by regulating astrocytic scaffold formation in the cortical hem.