Author

Devin T. Wehle

University of WashingtonORCID 0000-0002-9849-5667Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Stephen E.P. SmithiD· 3 shared Achira RoyiD· 1 shared Angela M. BardiD· 1 shared Breann Kniffen· 1 shared Carter S. Bass· 1 shared Emily A. BrowniD· 1 shared Felicia M. HarshiD· 1 shared Franck K. KalumeiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

Stephen E.P. SmithORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dissociation of the mTOR protein interaction network following neuronal activation is altered by Shank3 mutation

Devin T. Wehle, Emily A. Brown, Vera Stamenković, Breann Kniffen, Felicia M. Harsh, Stephen E.P. Smith

This study shows that Shank3 mutations alter how mTOR signaling networks dissociate in response to neuronal activation, affecting synaptic plasticity.

Journal of Neurochemistry · Jan 1, 2026Peer-reviewedBiochemistry

Protein interaction network analysis of mTOR signaling reveals modular organization

Devin T. Wehle, Carter S. Bass, Josef Šulc, Ghayda Mirzaa, Stephen E.P. Smith

The paper analyzes the mTOR protein interaction network to reveal its modular organization and how it responds to kinase inhibitors.

Journal of Biological Chemistry · Sep 21, 2023Peer-reviewedMolecular Biology

Suppression of PIK3CA-driven epileptiform activity by acute pathway control

Achira Roy, Victor Z. Han, Angela M. Bard, Devin T. Wehle, Stephen E.P. Smith, Jan‐Marino Ramirez, Franck K. Kalume, Kathleen J. Millen

The paper identifies PI3K and AKT inhibition as effective in suppressing PIK3CA-driven epileptiform activity in a mouse model, offering a potential therapeutic strategy for drug-resistant epilepsy.

bioRxiv · Mar 3, 2021 · PreprintNeuroscience