Franck K. Kalume

This study evaluates lentiviral vector delivery of SCN1A transgenes, finding that sequence optimization and epigenetic factors affect long-term expression.

This study shows that Ndufs4 knockout in glutamatergic neurons of mice leads to swallow-breathing discoordination, contributing to weight loss and early death, which is rescued by chronic hypoxia.

This study demonstrates that interneuron-specific AAV-mediated SCN1A gene replacement significantly rescues Dravet syndrome symptoms in mouse models.

The paper identifies PI3K and AKT inhibition as effective in suppressing PIK3CA-driven epileptiform activity in a mouse model, offering a potential therapeutic strategy for drug-resistant epilepsy.

SIESTA automates sleep staging in rodents using machine learning, achieving high F1 scores for wakefulness, REM, and NREM sleep stages.

The paper identifies two genetically-defined neuronal populations in Ndufs4KO mice that drive distinct pathological features of Leigh Syndrome.