Jan‐Marino Ramirez

This study investigates how Mecp2 deficiency affects swallow-related neuromuscular mechanisms in Rett Syndrome, finding impaired cholinergic signaling and submental muscle activity in Mecp2-deficient mice.

This study identifies fentanyl's off-target blockade of EAG-class potassium channels in motoneurons as a mechanism underlying Wooden Chest Syndrome, independent of opioid receptor activation.

The paper identifies an inspiration-off attractor mechanism that enables robust and flexible breathing control through GABAergic and glutamatergic signaling interactions in the VRC.

This study shows that activating RTN Phox2b+/Nmb+ neurons can counteract fentanyl-induced respiratory depression.

This study identifies PMPL-1 as a cofactor required for PEEL-1 toxin-induced cell death in C. elegans and shows that the toxin-antidote system creates a cation channel.

This study shows that Ndufs4 knockout in glutamatergic neurons of mice leads to swallow-breathing discoordination, contributing to weight loss and early death, which is rescued by chronic hypoxia.

This study identifies known pathogenic variants and new candidates in SUID using WGS, highlighting genetic factors related to heart disease and redox metabolism.

The paper analyzes neural population dynamics in the Ventral Respiratory Column to understand breathing, opioid-induced respiratory depression, and gasping.

This study demonstrates that interneuron-specific AAV-mediated SCN1A gene replacement significantly rescues Dravet syndrome symptoms in mouse models.

This study investigates how chronic intermittent hypoxia affects swallow behavior by examining the role of the Postinspiratory Complex in swallow-breathing coordination and motor patterning.

The paper presents an improved chromosome-scale genome assembly for the African spiny mouse using long Nanopore reads and validates it with RNA-seq data.

This study identifies the postinspiratory complex (PiCo) as a central gating mechanism that coordinates swallow and breathing behaviors through optogenetic experiments in mice.

This study identifies two mechanisms by which opioid activation disrupts inspiratory rhythm generation in the preBotC, leading to respiratory depression.

The paper identifies PI3K and AKT inhibition as effective in suppressing PIK3CA-driven epileptiform activity in a mouse model, offering a potential therapeutic strategy for drug-resistant epilepsy.

The paper investigates how substance P modulates breathing dynamics in the mouse preBötzinger complex by enhancing recurrent excitation between breaths, revealing a framework for dynamic control of breathing.