Emily A. Brown

This study shows that Shank3 mutations alter how mTOR signaling networks dissociate in response to neuronal activation, affecting synaptic plasticity.

An automated in-situ imaging platform reads 980 RNAs and 108 proteins in FFPE tissue at subcellular resolution, with 0.0092 false calls per cell; 800,000-plus cells released publicly.

The paper examines how different detergents affect activity-dependent synaptic protein interactions and finds that while detergent solubility varies, activity-dependent changes in protein complexes are consistent across detergents.