The paper investigates the role of YAP1 and TEAD1 in lineage segregation during human pre-implantation embryos, showing their involvement in trophectoderm and primitive endoderm formation independent of polarity.

Human Reproduction · May 24, 2023Peer-reviewedDevelopmental Biology

Differences in maternally inherited and age-related de novo mitochondrial DNA variants between ART and spontaneously conceived individuals associate with low birth weight

Joke Mertens, Florence Belva, Aafke P.A. van Montfoort, Filippo Zambelli, Sara Seneca, Edouard Couvreu de Deckersberg, M Bonduelle, Herman J. Tournaye, Katrien Stouffs, Kurt Barbé, Hubert J.M. Smeets, H. Van de Velde, Karen Sermon, Christophe Blockeel, Claudia Spits

The paper identifies mtDNA variants in ART and spontaneously conceived individuals linked to lower birth weight, showing sex-dependent effects and maternal aging influences.

medRxiv · Sep 5, 2022 · PreprintGenetic & Genomic Medicine

Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatally

Joke Mertens, Marius Regin, Neelke De Munck, Edouard Couvreu de Deckersberg, Florence Belva, Karen Sermon, Herman J. Tournaye, Christophe Blockeel, H. Van de Velde, Claudia Spits

The paper shows that mtDNA mosaicism arises early in human preimplantation development and persists into adulthood through asymmetric mitochondrial distribution.

Human Molecular Genetics · Mar 8, 2022Peer-reviewedGenetics