Author

P. H. Regan

Vanderbilt UniversityORCID 0000-0002-9870-182XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:imaging· 1

Frequent Co-Authors

Guoqiang GuiD· 2 shared Irina KaverinaiD· 2 shared Margret A. FyeiD· 2 shared Anissa Jayathilake· 1 shared Hudson McKinney· 1 shared Phyu Sin M. Myat· 1 shared Pranoy SangowdariD· 1 shared Rahul SharmaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

Guoqiang GuORCID

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2 papers

Recent·Most cited

Directed insulin secretion from beta cells occurs at cortical sites devoid of microtubules at the edges of ELKS/LL5β patches

Margret A. Fye, Pranoy Sangowdar, Anissa Jayathilake, P. H. Regan, Guoqiang Gu, Irina Kaverina

The paper shows that insulin secretion from beta cells occurs at specific cortical sites within ELKS/LL5β patches that lack microtubules, suggesting microtubule absence is critical for secretion.

Molecular Biology of the Cell · May 14, 2025Peer-reviewedCell Biology

A Comprehensive Workflow for Imaging Live Insulin Secretion Events and Granules in Intact Islets

Margret A. Fye, Rahul Sharma, Phyu Sin M. Myat, P. H. Regan, Hudson McKinney, Guoqiang Gu, Irina Kaverina

This paper presents a method to image insulin secretion and granule dynamics in live pancreatic islets using Zn2+-binding dyes and TIRF microscopy, revealing distinct secretion behaviors of different insulin granule pools.

bioRxiv · Apr 22, 2025 · PreprintCell Biology