Irina Kaverina

Diabetes-associated MYT1 and MYT3 regulate human beta-cell insulin secretion and survival via other diabetes-risk genes

This study shows MYT1 and ST18 regulate human beta-cell survival and insulin secretion under normal and stress conditions, with their genes enriched for T2D-risk loci.

CLASP1/2 REGULATE IMMUNE SYNAPSE MATURATION IN NATURAL KILLER CELLS

This study shows that CLASP1/2 stabilize Golgi-derived microtubules in NK cells, facilitating LFA-1 trafficking and immune synapse maturation.

Cell cycle-regulated tug-of-war between microtubule motors positions major trafficking organelles

The paper shows that CDK1-dependent motor activity regulates Golgi and ERES positioning during the cell cycle by switching between minus- and plus-end-directed forces.

Directed insulin secretion from beta cells occurs at cortical sites devoid of microtubules at the edges of ELKS/LL5β patches

The paper shows that insulin secretion from beta cells occurs at specific cortical sites within ELKS/LL5β patches that lack microtubules, suggesting microtubule absence is critical for secretion.

A Comprehensive Workflow for Imaging Live Insulin Secretion Events and Granules in Intact Islets

This paper presents a method to image insulin secretion and granule dynamics in live pancreatic islets using Zn2+-binding dyes and TIRF microscopy, revealing distinct secretion behaviors of different insulin granule pools.

Pancreatic islet alpha cells regulate microtubule stability in neighboring beta cells to tune insulin secretion and induce functional heterogeneity in individual mouse and human islets

The paper shows that alpha cells regulate beta cell microtubule stability via Gcg and Glp1 signaling, affecting insulin secretion and creating functional heterogeneity in islets.