Systems approaches identify the consequences ofmonosomy in somatic human cells
Narendra Kumar Chunduri, Paul Menges, Xiaoxiao Zhang, Angela Wieland, Vincent Leon Gotsmann, Balca R. Mardin, Christopher Buccitelli, Jan O. Korbel, Felix Willmund, Maik Kschischo, Markus Raeschle, Zuzana Štorchová
The paper investigates the effects of monosomy in human cells, finding that it impairs proliferation and genomic stability, with partial gene dosage compensation and ribosome biogenesis stress contributing to p53 pathway activation.
Nature Communications · Sep 22, 2021Peer-reviewedSystems Biology