Christopher Buccitelli

The paper investigates the effects of monosomy in human cells, finding that it impairs proliferation and genomic stability, with partial gene dosage compensation and ribosome biogenesis stress contributing to p53 pathway activation.

The paper uses bulk and single-cell transcriptomics to analyze SARS-CoV-2 infection in human cell lines, identifying HSP90 as a potential therapeutic target.

The paper describes an experimental strategy for mutating protein residues in mouse ESCs and introduces Mismatch-qPCR for detecting CRISPR editing events, while also showing RNA-Seq and low-coverage sequencing can detect large chromosomal deletions and rearrangements.