Crystal M. Ripplinger

Sex-specific electrophysiology and cholinergic responses underlie differential mechanisms of arrhythmia vulnerability in rabbit atria

This study examines sex differences in rabbit atrial electrophysiology and arrhythmia susceptibility, finding greater APD heterogeneity and cholinergic responses in females and males under different conditions.

Multi-parametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the Langendorff-perfused heart

The paper develops a multi-parametric imaging system to study cAMP, transmembrane potential, and calcium in the heart, showing cAMP activation correlates with electrophysiological responses.

Role of Dynamical Instability in QT Interval Variability and Early Afterdepolarization Propensity

This study shows that increased QT interval variability (QTV) can precede early afterdepolarizations (EADs) due to intrinsic dynamical instability in cardiac cells, offering an early warning signal for arrhythmia risk.

Sympathetic structural and electrophysiological remodeling in a rabbit model of reperfused myocardial infarction

This study investigates sympathetic remodeling in rabbit hearts after reperfused myocardial infarction, finding CSPGs correlate with reduced nerve density but preserved sympathetic responsiveness, leading to increased arrhythmia risk.

Quantitative cross-species translators of cardiac myocyte electrophysiology: model training, experimental validation, and applications

The paper develops statistical translators to map cardiac myocyte electrophysiological responses across species, validated with experimental data and simulations.