Molecular BiologybioRxivPreprint
Cytochrome P450 Enzyme Design by Constraining Catalytic Pocket in Diffusion model
Qian Wang, Xiaonan Liu, Hejian Zhang…·Huifeng Jiang
The paper designs artificial cytochrome P450 enzymes by applying a 'three-point fixation' model derived from structural and evolutionary analysis, resulting in enzymes with enhanced catalytic activity.