Huanyu Chu

Cytochrome P450 Enzyme Design by Constraining Catalytic Pocket in Diffusion model

The paper designs artificial cytochrome P450 enzymes by applying a 'three-point fixation' model derived from structural and evolutionary analysis, resulting in enzymes with enhanced catalytic activity.

Protein Engineering for Thermostability through Deep Evolution

This study develops DeepEvo, a deep learning approach for engineering thermostable proteins, achieving 8 highly thermostable variants from 30 generated sequences.

Hybrid Synthesis of bioplastics polyhydroxybutyrate from carbon dioxide

This paper describes a hybrid system that converts CO2 into bioplastic PHB using chemical and biological processes, achieving a carbon yield of 93.6% and a productivity of 1.06 g-1L-1h-1.

Designing a Minimal Artificial Glycolytic Pathway

This paper designs and tests a minimal artificial glycolytic pathway that efficiently converts various monosaccharides to acetyl-CoA with high yield.