Author

Hejian Zhang

Tianjin University of Science and TechnologyORCID 0009-0002-4199-4198Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 2 Approach:deep learning· 1 Approach:diffusion model· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Hong Yi ChangiD· 2 shared Huanyu ChuiD· 2 shared Huifeng JiangiD· 2 shared Jian ChengiD· 2 shared Chao ShiiD· 1 shared Dingyu LiuiD· 1 shared Jie BaiiD· 1 shared Jie BaiiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Hong Yi ChangORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 8, 2024

Cytochrome P450 Enzyme Design by Constraining Catalytic Pocket in Diffusion model

Qian Wang, Xiaonan Liu, Hejian Zhang…·Huifeng Jiang

The paper designs artificial cytochrome P450 enzymes by applying a 'three-point fixation' model derived from structural and evolutionary analysis, resulting in enzymes with enhanced catalytic activity.

3 citations

protein structurediffusion model

BioinformaticsbioRxivPreprintMay 4, 2023

Protein Engineering for Thermostability through Deep Evolution

Huanyu Chu, Zhenyang Tian, Lingling Hu…·Huifeng Jiang

This study develops DeepEvo, a deep learning approach for engineering thermostable proteins, achieving 8 highly thermostable variants from 30 generated sequences.

DOI 10.1101/2023.05.04.539497

protein sequencedeep learning