Lei Justan Zhang

Identification of lipid senolytics targeting senescent cells through ferroptosis induction

This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.

SomaMutDB 2.0: A comprehensive database for exploring somatic mutations and their functional impact in normal human tissues

SomaMutDB 2.0 is a database that catalogs 8.9 million somatic mutations from 10,852 samples and provides functional annotations to assess their impact in normal human tissues.

Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair

This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.

SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.

Minimally Invasive DNA-Mediated Photostabilization for Extended Single-Molecule and Super-resolution Imaging

This paper develops a DNA-mediated photostabilization method for single-molecule and super-resolution imaging, showing improved performance at lower additive concentrations and enabling continuous replenishment of photostabilizers.

Development of novel flavonoid senolytics through phenotypic drug screening and drug design

This study develops two novel flavonoid senolytics through phenotypic drug screening and design, showing enhanced senolytic activity and healthspan extension in a mouse model.

Cytochrome P450 Enzyme Design by Constraining Catalytic Pocket in Diffusion model

The paper designs artificial cytochrome P450 enzymes by applying a 'three-point fixation' model derived from structural and evolutionary analysis, resulting in enzymes with enhanced catalytic activity.

Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.

CDCP: a visualization and analyzing platform for single-cell datasets

CDCP is a platform for sharing and analyzing single-cell datasets, offering visualization and analysis tools for researchers.