Janine F. Felix

The prenatal exposome and genome in predictive modelling of DNA methylation

This study integrates prenatal exposures and genetics to predict DNA methylation at birth, finding that the exposome explains additional variation beyond genetic factors.

Epigenetic and brain age across development: Performance and associations in the MIND consortium

Across 15 cohorts (birth to 24 years), 20 epigenetic clocks and eight brain age models predicted chronological age modestly, stabilizing by middle childhood; their age residuals were weakly associated.

Epigenome-wide association study meta-analysis of wellbeing

This study conducts an epigenome-wide association study (EWAS) meta-analysis of wellbeing using DNA methylation data, finding no significant methylation sites but suggesting the need for larger studies.

Development of a microRNA clock for gestational age in the general population

This paper develops a miRNA-based gestational age clock (miRClock-GA) using cord blood plasma miRNA data and validates it in an independent cohort, showing associations with birthweight and childhood BMI.

Direct and Indirect Genetic Effects of Birthweight Predisposition on Child DNA Methylation at Birth

This study investigates whether genetic birthweight predisposition, through direct or indirect effects, is associated with DNA methylation at birth and identifies six methylation sites linked to maternal indirect effects.

Identification of Dynamic Genetic Influences on DNA Methylation from Birth to Adulthood

The paper identifies age-dependent methylation quantitative trait loci (longitudinal mQTLs) across the lifespan using blood DNAm data from two cohorts, finding consistent genotype-by-age effects and associations with multiple phenotypes.

Cell type-specific methylome-wide association studies of childhood ADHD symptoms

This study identifies cell type-specific DNA methylation associations with childhood ADHD symptoms using deconvolution and sequencing-based methylation data from peripheral and cord blood.

Genetic Nurture: Estimating the direct genetic effects of pediatric anthropometric traits

This study estimates direct and indirect genetic effects on pediatric anthropometric traits in a Dutch cohort, finding significant direct effects but limited indirect genetic nurture influence.

What makes clocks tick? Characterizing developmental dynamics of adult epigenetic clock sites

The paper characterizes the developmental trajectories of adult epigenetic clock sites using longitudinal cohort data, finding divergent patterns, early individual variation, and enrichment for genetic and prenatal environmental factors.

Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

This study uses longitudinal meta-regression to examine how DNA methylation effects on child health outcomes vary by timing, finding larger effects in childhood but noisier associations and time-specific signals.

An epigenome-wide association study of child appetitive traits and DNA methylation

This study identifies regional DNA methylation associations with early childhood appetitive traits using epigenome-wide analysis of cord blood samples.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Epigenome-wide contributions to individual differences in childhood phenotypes: A GREML approach

The paper estimates the variance explained by DNA methylation at birth for childhood phenotypes using GREML, finding moderate to large contributions for gestational age and birth weight but near-zero for BMI, IQ, and ADHD symptoms.

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.

This study examines DNA methylation at birth and its association with childhood cognitive skills, finding weak single CpG site associations and one region near DUSP22 linked to non-verbal cognition.

Genome Wide Association Metanalysis Of Skull Bone Mineral Density Identifies Loci Relevant For Osteoporosis And Craniosynostosis

This study identifies 59 genome-wide significant loci for skull bone mineral density, including four novel loci, and links them to osteoporosis and craniofacial developmental defects.

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

Identifying Causative Mechanisms Linking Early-Life Stress to Psycho-Cardio-Metabolic Multi-Morbidity: The EarlyCause Project

The paper outlines the protocol for the EarlyCause project, which investigates the biological mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity using longitudinal data, animal models, and cellular systems.

Epigenome-wide change and variation in DNA methylation from birth to late adolescence

The paper analyzes DNA methylation changes across birth to late adolescence in two cohorts, finding widespread nonlinear changes and sex-specific patterns.

Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis

This study identifies DNA methylation sites at birth associated with ADHD symptoms later in childhood, but finds no such associations at school age.

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data

The paper evaluates and validates reference and library selection methods for deconvolving cord blood DNA methylation data, finding that the IDOL library outperforms automatic selection methods.

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.

Differences in DNA methylation of white blood cell types at birth and in adulthood reflect postnatal immune maturation and influence accuracy of cell type prediction

The paper examines DNA methylation differences in white blood cell types between newborn and adult blood, showing how these changes reflect immune maturation and affect cell type prediction accuracy.

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

This study identifies maternal genetic variants associated with offspring birth weight using GWAS and SEM, showing independent effects from fetal genetics.

Maternal and fetal genetic contribution to gestational weight gain

This study investigates the genetic contributions to gestational weight gain, finding that maternal common variants explain about 20% of variability, while fetal variants have a minor role.

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.