Sandrine Thuret

This study shows that adult social isolation in mice increases miR-30e-5p expression in the hippocampus, reduces its target gene Neurod1, and impairs pattern separation without affecting anxiety or depression-like behaviors.

The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

This study identifies TNF-α-induced type I IFN signaling as a mechanism suppressing neurogenesis and recruiting T cells in human hippocampal progenitor cells.

This study transplants gut microbiota from Alzheimer's patients into rats, showing impaired neurogenesis and cognitive behaviors, suggesting a causal link between gut microbiota and Alzheimer's symptoms.

This study models telomere shortening in human hippocampal progenitor cells and links it to reduced neurogenesis, cognitive impairment, and psychiatric disorder risk.

This study identifies miR-132 deficiency as a cause of impaired adult hippocampal neurogenesis in Alzheimer's disease and shows that restoring miR-132 levels can reverse these deficits and memory issues.

The paper identifies 19 compounds from the CMAP library that show significant inverse correlation with Alzheimer's disease transcriptome signatures and pass in vitro screening assays.

This study shows that serum from MCI patients predicts AD conversion up to 3.5 years before diagnosis by altering hippocampal progenitor cell behavior.