Tania Sorg

This study shows that astroglial Ophn1 deficiency impairs synaptic transmission and behavior, with potential therapeutic targeting of the RhoA/ROCK pathway.

This study investigates the effects of Dyrk1a gene dosage in glutamatergic neurons on cognitive deficits in MRD7 and Down syndrome mouse models, finding specific roles in long-term explicit memory.

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

The paper outlines the protocol for the EarlyCause project, which investigates the biological mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity using longitudinal data, animal models, and cellular systems.

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

The paper introduces a method called soft windowing to improve analysis of high-throughput phenotyping data by reducing false positives and increasing significant results.