Madison Morales

Pooled amplicon sequencing for characterizing mutations in the praziquantel molecular target TRPMPZQ in schistosome populations from Western Kenya

This study analyzes mutations in the Praziquantel target gene Sm.TRPMPZQ in schistosome populations from Western Kenya to assess their role in drug resistance.

Direct measurement of in vitro response to Praziquantel in Schistosoma mansoni populations from Western Kenya

The paper directly assays PZQ response in S. mansoni worms from Western Kenya and finds no evidence of PZQ resistance.

Abundant genetic variation is retained in many laboratory schistosome populations

This study finds that laboratory Schistosoma mansoni populations retain abundant genetic variation, with implications for drug resistance studies and GWAS.

Rapid phenotypic and genotypic change in a laboratory schistosome population

The paper detects recent contamination in a laboratory Schistosoma mansoni population and shows how genetic drift causes divergence in parasite populations over time.