This study examines age-dependent behavioral changes in Cntnap2 knockout mice, finding increased reactivity and reduced nesting in older females, while no differences were observed in wild-type controls.

bioRxiv · Jan 23, 2026 · PreprintNeuroscience

MicroRNA-218 instructs proper assembly of hippocampal networks

Seth R. Taylor, Mariko Kobayashi, Antonietta Vilella, Durgesh Tiwari, Norjin Zolboot, Jessica Xinyun Du, Kathryn R. Spencer, Andrea L. Hartzell, Carol B.L. Girgiss, Yusuf T Abaci, Yufeng Shao, Claudia De Sanctis, Gian Carlo Bellenchi, Robert B. Darnell, Christina Groß, , Giordano Lippi

This study identifies miR-218 as critical for hippocampal network stability by regulating interneuron function during early development.

eLife · Oct 20, 2023Peer-reviewedNeuroscience

MiR-324-5p regulates the structure of dendritic spines and is essential for hippocampal long-term potentiation

Emma V. Parkins, Darrin H. Brager, Jeffrey K. Rymer, John M. Burwinkel, Diego Rojas, Durgesh Tiwari, Yueh‐Chiang Hu, Christina Groß

This study shows that miR-324-5p regulates dendritic spine structure and hippocampal long-term potentiation in mice by affecting synaptic proteins and plasticity.

bioRxiv · Jul 19, 2023 · PreprintNeuroscience