Seth R. Taylor

Intrinsic and non-cell autonomous roles for a neurodevelopmental syndrome-linked transcription factor

The paper identifies both cell-autonomous and non-cell-autonomous roles of UNC-3 in C. elegans motor neurons, revealing its impact on neuronal identity and downstream connectivity.

A gene expression atlas of a juvenile nervous system

This study creates a gene expression atlas of C. elegans L1 neurons, identifying differentially expressed genes and regulatory networks involved in postembryonic neurogenesis and maturation.

The forkhead transcription factor FKH-7/FOXP acts in chemosensory neurons to regulate developmental decision-making

This study identifies a role for FKH-7/FOXP in chemosensory neurons regulating developmental decision-making and links it to autism-associated gene variants.

Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons

The paper integrates bulk and single-cell RNA-seq data from C. elegans neurons to improve transcript detection and differential gene analysis.

Alternative splicing across the C. elegans nervous system

The paper presents an atlas of alternative splicing in C. elegans neurons, identifies novel splicing events, and describes regulatory patterns and networks.

MicroRNA-218 instructs proper assembly of hippocampal networks

This study identifies miR-218 as critical for hippocampal network stability by regulating interneuron function during early development.

A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes

The paper creates a molecular atlas of adult C. elegans motor neurons, identifying 29 subclasses defined by transcription factor and neuropeptide codes, and shows conservation between C. elegans and mice.

The neuropeptidergic connectome of C. elegans

The paper generates a draft connectome of neuropeptide signaling in C. elegans by integrating single-cell data with biochemical analysis.

ACh signaling modulates activity of the GABAergic signaling network in the basolateral amygdala and behavior in stress-relevant paradigms.

This study shows that acetylcholine modulates GABAergic signaling in the basolateral amygdala, altering the balance of inhibitory neuron subtypes and affecting stress-related behaviors.

Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons

The paper integrates bulk and single-cell RNA-seq data from C. elegans neurons to improve transcript detection and differential gene analysis.

Molecular topography of an entire nervous system

The paper provides a comprehensive gene expression profile of all 302 neurons in the C. elegans nervous system and identifies cis-regulatory elements and adhesion proteins involved in synaptic specificity.

An optimized ribodepletion approach for C. elegans RNA-sequencing libraries

The paper compares two RNA-seq library preparation methods for C. elegans, finding that SoLo Ovation with a custom rRNA depletion kit improves detection of noncoding RNAs and reduces noise in lowly expressed genes.

Expression profiling of the mature C. elegans nervous system by single-cell RNA-Sequencing

Transcriptomes of 52,412 neurons resolve 109 of the 118 canonical hermaphrodite neuron classes, and neuropeptide genes separate subtypes inside individual classes.