Xin Yan

This paper uses copper-free click chemistry to engineer mitochondria-targeted brain-derived exosomes, preserving their structure and function while enabling targeted delivery and imaging.

The paper introduces MitoFlare, a reversible mitochondrial ROS probe, and demonstrates its application in quantifying mitophagy dynamics in real time using a dual-probe imaging platform.

This paper introduces a novel mitochondrial-targeting dye, Cy5-PEG4, for in vivo brain imaging and neurodegenerative disease studies, showing improved BBB penetration and reduced toxicity.

The paper develops a mitochondria-targeting fluorescent dye, Cy5-PEG2, for in vivo brain imaging and assesses its safety in brain regions.

This study designs and evaluates mitochondria-targeting exosomes for treating brain tumors and neurodegenerative diseases using in vitro and in vivo tests.

This study investigates the therapeutic potential of IADB in ALS models, showing it promotes autophagy and reduces mutant SOD1 aggregates, oxidative stress, and disease progression.