Stella E. Tsirka

This study establishes a murine model of age-dependent Powassan virus (POWV) lethality, revealing divergent neuroinflammatory cytokine responses in young and old mice that correlate with CNS viral clearance and disease severity.

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

The paper identifies a unique microglial subset at the tumor-stroma interface in gliomas that correlates with poor prognosis and suggests it as a therapeutic target.