Carlos A. Toro

An Implantable Poly(pro-curcumin) Film for Local, Long-Lasting Neuroprotection After Spinal Cord Injury

This paper introduces an implantable poly(pro-curcumin) film that provides long-lasting neuroprotection after spinal cord injury by locally delivering curcumin, improving locomotor recovery and reducing inflammation.

Boldine inhibits SARM1 NADase Activity and Preserves Axonal Integrity After Nerve Injury

Oral Administration of Boldine Reduces Spare Nerve Injury-Induced Neuropathic Pain

This study shows that oral boldine reduces neuropathic pain in mice by inhibiting inflammation and glial activation.

Central Nervous System axonal regeneration by spatially targeted drug combinations

This study identifies a four-drug combination that promotes axonal regeneration in the optic nerve of rats by targeting subcellular processes, leading to functional recovery.

Spinal Cord Injury regulates circular RNA expression in axons

The paper identifies SCI-induced changes in axonal RNA, including circular RNAs, and shows that reducing ADAR1 promotes axonal outgrowth.

Boldine modulates glial transcription and functional recovery in a murine model of contusion spinal cord injury

Boldine improves locomotor function and reduces glial activation in a mouse model of spinal cord injury by modulating calcium signaling and gene expression.

Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

The human ApoE4 variant reduces functional recovery and neuronal sprouting after incomplete spinal cord injury in male mice

This study shows that the ApoE4 variant in mice leads to worse recovery and reduced neuronal sprouting after spinal cord injury compared to ApoE3.

Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression

The paper shows that EED represses Kdm6b, increasing H3K27me3 and reducing gene expression in a puberty-activating network.

Elucidating the genetic architecture of reproductive ageing in the Japanese population

This study identifies 26 genetic loci associated with reproductive ageing in a Japanese population, highlighting differences in allele frequencies and effect estimates compared to European populations.