Timofei S. Zatsepin

This paper modifies thrombin aptamers with specific nucleotides to enhance affinity and introduce Ag+ dependency.

This study shows that downregulating Gankyrin/PSMD10 in glioblastoma cells reduces proliferation, increases apoptosis, and enhances chemotherapy effectiveness in vitro and in vivo.

The paper investigates pH-dependent i-motif folding in a duplex context and shows stabilization near the i-motif-duplex junction.

The paper identifies TP63 and TRIM29 as regulators of enhancer methylation and chromosomal instability in prostate cancer by integrating multi-omics data from The Cancer Genome Atlas.

This study shows that hepatocyte differentiation requires anisotropic expansion of bile canaliculi, with loss of polarity leading to cholangiocyte-like gene expression.

This paper develops an mRNA platform for delivering single-domain antibodies, achieving 100% protection against high doses of botulinum neurotoxin A in mice.