Li Wang

This paper develops a humanized mouse model of prenatal Zika infection and shows it mimics human phenotypes, including disrupted neural stem cells and brain injuries.

This study defines the structural states and curvature-based activation/inactivation mechanisms of PIEZO1 using a mutant and molecular dynamics simulations.

This paper identifies how Piezo1 channels are tethered to the actin cytoskeleton via the E-cadherin-β-catenin complex, enabling mechanogating through direct force transmission.

This study shows that sevoflurane exposure disrupts astrocyte function, leading to synaptic overgrowth and dysfunction in developing brains.