Xinnan Wang

This study identifies MIRO1 as a context-specific modulator of BAX activity, showing it drives distinct cell death pathways in glioma cells and Parkinsonian neurons through different mechanisms.

The paper integrates cross-species transcriptomic data to identify a MIRO1-mediated macrophage-T cell axis in glioma that contributes to immunosuppression.

The paper introduces optogenetic proximity labeling to map mitochondrial surface proteomes and ribosome pools, revealing Miro1's role in spatially organizing mitochondrial protein biogenesis.

This study shows that mitochondrial Complex I depletion in Drosophila neuromuscular junctions leads to opposing effects on pre- and postsynaptic function through ROS-dependent mechanisms.