Sergio E. Baranzini

The paper identifies innate immune activation and CMV-specific antibody reactivity as early markers of preclinical NMOSD, preceding clinical onset by over 12 years.

The paper identifies a female-enriched gut bacterium, Eggerthella lenta, that drives neuroinflammation and IFN-γ via TLR2 in autoimmune disease models.

Paired CSF and blood scRNA/TCR-seq in treatment-naive MS shows a small set of expanded, cytotoxic CSF-enriched CD8+ clonotypes, two of which recognize EBV epitopes.

This study uses machine learning to assess how 3D genome structure affects height by analyzing GWAS data and predicting variant impacts on chromatin contacts.

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

The paper reports a detailed genetic and genomic map of multiple sclerosis, identifying susceptibility genes in peripheral immune cells and brain-resident microglia.

The paper integrates biomedical research with electronic health records to create biologically meaningful machine-readable embeddings for precision medicine.

This paper uses a biomedical knowledge network to predict drug-disease treatment pairs and prioritize drug repurposing candidates.