Michael R. Wilson

Innate Immune Dysregulation Precedes Clinical Onset in Neuromyelitis Optica

The paper identifies innate immune activation and CMV-specific antibody reactivity as early markers of preclinical NMOSD, preceding clinical onset by over 12 years.

Longitudinal linear-epitope profiling of SLE identifies novel antigens associated with disease and disease activity

This study identifies novel SLE autoantigens and links EBV-driven immunity to autoimmunity through longitudinal PhIP-seq and machine learning analysis.

AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD

AEGIS identifies epitope- and clone-specific autoimmunity in ROHHAD by linking immune repertoires to self-epitopes, revealing convergence on ZSCAN1 epitopes in the CNS.

Autoreactomes in Healthy Individuals Vary According to HLA Class II Genotype

This study identifies distinct autoreactomes in healthy individuals based on HLA-DRB1 genotype using PhIP-Seq, showing genotype-specific autoantibody profiles and potential pathogenic autoantibodies before disease onset.

Antigen-specificity of clonally-enriched CD8+ T cells in multiple sclerosis

Paired CSF and blood scRNA/TCR-seq in treatment-naive MS shows a small set of expanded, cytotoxic CSF-enriched CD8+ clonotypes, two of which recognize EBV epitopes.

Structure-guided design of a targeted autoantibody degrader for neurologic disease

This paper designs a targeted autoantibody degrader to treat neurologic diseases by specifically clearing pathogenic autoantibodies while preserving the immune system.

Disrupted callosal connectivity underlies long-lasting sensory-motor deficits in an NMDA receptor antibody encephalitis mouse model

This study shows that exposure to anti-GluN1 mAb during development causes long-term sensory-motor deficits and callosal axon changes in mice.

Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping

This study identifies immune subtypes in hospitalized COVID-19 patients linked to clinical outcomes and long COVID risk through longitudinal multi-omics analysis.

Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19

This study investigates viral reactivation in COVID-19 patients, finding associations between reactivation of specific virus families and clinical outcomes, including mortality and PASC symptoms.

Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal Leukoencephalopathy

The paper identifies JCV VP1 epitopes recognized by HLA-A2 and isolates TCRs that recognize these epitopes, showing cytotoxic activity against infected cells.

Unbiased metagenomic sequencing for pediatric meningitis in Bangladesh reveals neuroinvasive Chikungunya virus outbreak and other unrealized pathogens

This study uses metagenomic sequencing to identify pathogens in pediatric meningitis cases in Bangladesh, revealing a Chikungunya virus outbreak and other previously undetected causes.

Integrating Host Response and Unbiased Microbe Detection for Lower Respiratory Tract Infection Diagnosis in Critically Ill Adults

This paper develops a metagenomic sequencing approach to diagnose lower respiratory tract infections by integrating pathogen detection, microbiome analysis, and host transcriptome data.

Pediatric Brainstem Encephalitis Outbreak Investigation with Metagenomic Next-Generation Sequencing

The paper investigates a pediatric brainstem encephalitis outbreak using metagenomic next-generation sequencing, finding that mNGS significantly improves EV-A71 detection in CSF and confirms the outbreak strain's relation to a neuroinvasive isolate.

Etiology of fever in Ugandan children: identification of microbial pathogens using metagenomic next-generation sequencing and IDseq, a platform for unbiased metagenomic analysis

This study uses metagenomic sequencing and the IDseq platform to identify microbial pathogens in Ugandan children with fever, revealing common pathogens and novel viruses.

Evidence for Alternative Complement Cascade Activation in Primary CNS Vasculitis

The paper analyzes cerebrospinal fluid proteomes to identify complement pathway activation in PACNS, suggesting C5 inhibitors as potential therapies.

Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients

This study uses metagenomic sequencing to detect respiratory pathogens in hematopoietic transplant patients, finding it more sensitive than conventional methods and identifying new pathogens.