Author

Daniel Spies

University of ZurichORCID 0000-0003-0072-0799Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Constance CiaudoiD· 2 shared Richard Patryk NgondoiD· 2 shared Amena NabihiD· 1 shared Ameya KhandekariD· 1 shared Ataman SendoeliD· 1 shared Chenke Shi· 1 shared Clara DuréiD· 1 shared David GatfieldiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Constance CiaudoORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintMar 17, 2025

In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component

Fabiola Valdivia-Francia, Umesh Ghoshdastider, Peter F. Renz…·Ataman Sendoel

The paper uses in vivo single-cell CRISPR screening in mouse epidermis to identify a microprotein critical for ribosome function and cell proliferation.

3 citations

mouseCRISPR screen

𝕏 PostBluesky

Molecular BiologyStem Cell ReportsPeer-reviewedApr 21, 2022

ARGONAUTE proteins regulate a specific network of genes through KLF4 in mouse embryonic stem cells

Madlen Müller, Moritz Schaefer, Tara Fäh…·Constance Ciaudo

The paper identifies KLF4 as a key transcription factor modulating gene expression in Ago mutant mouse embryonic stem cells, revealing noncanonical AGO functions beyond miRNA regulation.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky

Systems BiologybioRxivPreprintSep 24, 2021

Integrative analysis allows a global and precise identification of functional miRNA target genes in mESCs

Moritz Schäfer, Amena Nabih, Daniel Spies…·Constance Ciaudo

The paper identifies that only 6% of expressed genes are functionally regulated by miRNAs in mESCs using integrative analysis of transcriptome data and miRNA interaction predictions.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky