Constance Ciaudo

This study shows that LBR and LAP2 tether heterochromatin to the nuclear periphery, and their loss disrupts genome homeostasis by repositioning heterochromatin and altering gene expression.

This study determines the solution structure of DND1 bound to AU-rich RNA, revealing a novel tandem RRM-RNA recognition mechanism essential for mRNA regulation.

The paper identifies KLF4 as a key transcription factor modulating gene expression in Ago mutant mouse embryonic stem cells, revealing noncanonical AGO functions beyond miRNA regulation.

The paper identifies that only 6% of expressed genes are functionally regulated by miRNAs in mESCs using integrative analysis of transcriptome data and miRNA interaction predictions.

The paper shows that translation is required for miRNA-dependent transcript decay, as non-translated lncRNAs are minimally affected by miRNA loss, while translated transcripts are destabilized.

This study shows that covalently linking a DNA repair template to the CRISPR/Cas9 complex increases HDR efficiency 23-fold compared to NHEJ.