Author

Shiva K. Tyagarajan

University of ZurichORCID 0000-0003-0074-1805Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Assay:electronic health records· 1

Frequent Co-Authors

Benjamin F. N. CampbelliD· 3 shared Andreas PlückthuniD· 2 shared Giovanna Bosshard· 2 shared Patrizia PanzanelliiD· 2 shared Amalia Floriou‐ServouiD· 1 shared Andrin Abegg· 1 shared Anna CavacciniiD· 1 shared Antje DittmanniD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersNeuroscience

Benjamin F. N. CampbellORCID

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Author profile →

6 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedApr 16, 2026

Cryo-EM Structures of Higher Order Gephyrin OligomersReveal Principles of Inhibitory Postsynaptic Scaffold Organization

Diego Ortiz-López, Tamsanqa Tafara Hove, Christiane Huhn…·Hermann Schindelin

This study determines the structure of higher-order gephyrin oligomers using cryo-EM, revealing how its flexible linker regulates receptor binding and oligomerization.

3 citationstop 4%

protein structureexperimental assay

𝕏 PostBluesky

NeuroscienceeLifePeer-reviewedOct 31, 2022

A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology

Benjamin F. N. Campbell, Antje Dittmann, Birgit Dreier…·Shiva K. Tyagarajan

This study develops DARPin-based tools to study gephyrin and inhibitory synapses, revealing new interactors and binding modes.

14 citations

mouseproteomics

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NeuroscienceScience AdvancesPeer-reviewedMar 4, 2022

Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia

Teresa L.M. Cramer, Raminder Gill, Zahra S. Thirouin…·Shiva K. Tyagarajan

63 citationstop 4%

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 25, 2020

Differential impact of GABAA receptors and gephyrin post-translational modifications on layer 2/3 pyramidal neuron responsiveness in vivo

Yuan-Chen Tsai, Mohammad Hleihil, Kanako Otomo…·Shiva K. Tyagarajan

The paper investigates how GABAA receptor subtypes and gephyrin post-translational modifications influence layer 2/3 pyramidal neuron responsiveness in mouse barrel cortex during sensory processing.

DOI 10.1101/2020.11.25.397877

mouseelectronic health records

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NeuroscienceNature CommunicationsPeer-reviewedOct 5, 2020

Surfaceome dynamics during neuronal development and synaptic plasticity reveal system-wide surfaceome reorganization independent of global proteostasis

Marc van Oostrum, Benjamin F. N. Campbell, Charlotte Seng…·Bernd Wollscheid

The paper analyzes surfaceome dynamics during neuronal development and synaptic plasticity, revealing surface protein reorganization independent of global proteostasis.

49 citations

mouseproteomics

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NeurosciencePLoS GeneticsPeer-reviewedOct 25, 2017

RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of a2 GABAA receptors

Claire de Groot, Amalia Floriou‐Servou, Yuan‐Chen Tsai…·Shiva K. Tyagarajan

This study investigates how splice isoforms of collybistin (CB1 and CB2) regulate neuronal maturation and synapse formation through their effects on Cdc42 and GABAAR signaling in the developing brain.

17 citations

mouseexperimental assay

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