Marc van Oostrum

The paper shows that mouse neural organoids can replicate the synaptic proteome of mature brains through optimized protocols and proteomics analysis.

The paper profiles synaptic transcriptomes across five brain regions in mice, identifying mRNAs enriched at synapses and their role in synaptic diversity and function.

This study identifies POMP as a stress-induced transcriptional regulator that buffers proteasome dysfunction through a non-canonical role in nucleolar RNA processing.

The paper constructs a tissue-specific protein interaction atlas using proteomic data from 11 human tissues, identifying key drivers of inter-tissue variation and prioritizing disease genes in brain disorders.

The paper identifies synapse type-enriched proteins and their functional associations across brain regions and cell types using proteomic analysis.

This paper introduces LUX-MS, a light-triggered optoproteomic technology to map surfaceome receptor interactions and nanoscale organization, revealing insights into intercellular signaling and drug action.

This study shows that enzymatic dissociation of brain tissue alters transcriptomic and proteotype profiles compared to mechanical dissociation.

The paper analyzes surfaceome dynamics during neuronal development and synaptic plasticity, revealing surface protein reorganization independent of global proteostasis.