Chris M. Brown

The paper identifies structured RNA motifs and Aca proteins that regulate anti-CRISPR gene expression in bacteriophages, revealing new regulatory mechanisms beyond DNA-binding HTH regulators.

This paper identifies viral single-guide RNAs (vsgRNAs) that subvert bacterial CRISPR-Cas9 immunity by sequestering Cas9 and redirecting its activity, and shows they can enable genome editing in mammalian cells.

This paper uses AI to analyze HBV splicing patterns and shows that splicing efficiency correlates with disease severity, revealing similarities between HBV and host splice sites.

This study shows that mycobacterial Rho forms liquid-liquid phase separation condensates under acid stress, which may help cells tolerate stress by terminating transcription.

RIBOSS integrates long- and short-read sequencing to detect novel translational events in prokaryotic and eukaryotic transcriptomes.

This study analyzes Rho factor diversity in bacterial genomes, finding that most bacteria have atypical Rho structures with novel features and potential functional roles.