Author

Christine Happle

Medizinische Hochschule HannoverORCID 0000-0003-0096-3272Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Georg M. N. BehrensiD· 3 shared Inga NehlmeieriD· 3 shared Markus HoffmanniD· 3 shared Alexandra Dopfer‐JablonkaiD· 2 shared Lu ZhangiD· 2 shared Nianzhen CheniD· 2 shared Stefan PöhlmanniD· 2 shared Amy Eichmann· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMicrobiology

Georg M. N. BehrensORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 8, 2026

Epidemiology and virological characteristics of the emerging SARS-CoV-2 variant PJ.2.1

Markus Hoffmann, Lu Zhang, Nianzhen Chen…·Stefan Poehlmann

The paper characterizes the epidemiology and virology of the SARS-CoV-2 variant PJ.2.1, finding it spreads mainly in older adults and shows increased ACE2 binding but not greater antibody evasion.

DOI 10.64898/2026.10.08.757354

virusexperimental assay

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MicrobiologyJournal of VirologyPeer-reviewedAug 5, 2026

The conserved QTQTX motif in the SARS-CoV-2 spike protein is dispensable for cleavage and lung cell entry of the emerging variant BA.3.2

Lu Zhang, Nianzhen Chen, Amy Eichmann…·Stefan Pöhlmann

This study shows the QTQTX motif in BA.3.2 S protein is not required for cleavage or lung cell entry, which depends on TMPRSS2 instead.

DOI 10.1128/jvi.00691-26

humanproteomics

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Molecular BiologyThe Lancet Infectious DiseasesPeer-reviewedNov 7, 2024

Impact of JN.1 booster vaccination on neutralisation of SARS-CoV-2 variants KP.3.1.1 and XEC

Prerna Arora, Christine Happle, Amy Madeleine Kempf…·Markus Hoffmann

The paper characterizes the XEC SARS-CoV-2 lineage and evaluates the neutralization effect of JN.1 booster vaccination against KP.3.1.1 and XEC variants.

45 citationstop 1%

experimental assay

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