The paper characterizes the XEC SARS-CoV-2 lineage and evaluates the neutralization effect of JN.1 booster vaccination against KP.3.1.1 and XEC variants.

The Lancet Infectious Diseases · Nov 7, 2024Peer-reviewedMolecular Biology

Interferon induction and not replication interference mainly determines anti-influenza virus activity of defective interfering particles

Prerna Arora, Najat Bdeir, Sabine Gärtner, Stefanie Reiter, Lars Pelz, Ulrike Felgenhauer, Udo Reichl, Stephan Ludwig, Friedemann Weber, Markus Hoffmann, Michael Winkler, Stefan Pöhlmann

This study shows that defective interfering particles (DIPs) primarily exert antiviral activity through interferon (IFN) system activation rather than suppression of viral replication.

bioRxiv · Sep 20, 2021 · PreprintMolecular Biology

SARS-CoV-2 variant B.1.617 is resistant to Bamlanivimab and evades antibodies induced by infection and vaccination

Markus Hoffmann, Heike Hofmann-Winkler, Nadine Krüger, Amy Madeleine Kempf, Inga Nehlmeier, Luise Graichen, Prerna Arora, Anzhalika Sidarovich, Anna-Sophie Moldenhauer, Martin Sebastian Winkler, Sebastian R. Schulz, Hans‐Martin Jäck, Metodi V. Stankov, Georg M. N. Behrens, Stefan Pöhlmann

Cell Reports · Jun 29, 2021Peer-reviewedMolecular Biology

Increased lung cell entry of B.1.617.2 and evasion of antibodies induced by infection and BNT162b2 vaccination

Prerna Arora, Amy Madeleine Kempf, Inga Nehlmeier, Anzhalika Sidarovich, Nadine Krüger, Luise Graichen, Anna-Sophie Moldenhauer, Martin Sebastian Winkler, Sebastian R. Schulz, Hans‐Martin Jäck, Metodi V. Stankov, Georg M. N. Behrens, Stefan Pöhlmann, Markus Hoffmann

This study shows that the B.1.617.2 variant of SARS-CoV-2 evades antibodies from infection and vaccination, increases lung cell entry, and enhances cell fusion.

bioRxiv · Jun 23, 2021 · PreprintMolecular Biology

SARS-CoV-2 variants B.1.351 and B.1.1.248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination

Markus Hoffmann, Prerna Arora, Rüdiger M. Groß, Alina Seidel, Bojan F. Hörnich, Alexander S. Hahn, Nadine Krüger, Luise Graichen, Heike Hofmann-Winkler, Amy Madeleine Kempf, Martin Sebastian Winkler, Sebastian R. Schulz, Hans‐Martin Jäck, Bernd Jahrsdörfer, Hubert Schrezenmeier, , Stefan Pöhlmann

Cell · Mar 20, 2021Peer-reviewedMolecular Biology

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

Markus Hoffmann, Heike Hofmann-Winkler, Joan C. Smith, Nadine Krüger, Prerna Arora, Lambert K. Sørensen, Ole Schmeltz Søgaard, Jørgen Bo Hasselstrøm, Michael Winkler, Tim Hempel, Lluı́s Raich, Simon Olsson, Olga Danov, Danny David Jonigk, Takashi Yamazoe, , Stefan Pöhlmann

This study shows camostat mesylate inhibits SARS-CoV-2 by blocking TMPRSS2 and its metabolite GBPA also has antiviral activity, suggesting no resistance through TMPRSS2-related proteases.

EBioMedicine · Mar 1, 2021Peer-reviewedMolecular Biology