Jonatan Martínez‐Gardeazabal

Synthesis and pharmacological characterization of UVI3502, a novel cannabinoid receptor 1 (CB1) antagonist/inverse agonist

This paper synthesizes and characterizes UVI3502, a novel CB1 receptor antagonist/inverse agonist, showing high affinity for CB1 and low affinity for CB2, with potential interactions with GPR55.

Cannabinoid agonist WIN55,212-2 prevents scopolamine-induced impairment of spatial memory

This study shows that WIN55,212-2 prevents scopolamine-induced spatial memory impairment by increasing cannabinoid receptor density and muscarinic tone in cortical areas.

Cortical lipids containing choline mediate cannabinoid-induced cognitive improvement

This study shows that CB1 agonist WIN55,212-2 improves memory and increases cortical ACh and choline-containing lipids in cholinergic lesion models.

Cell lipotypes localization in brain by mass spectrometry imaging

The paper defines lipid profiles for five brain cell types and maps their spatial distribution using mass spectrometry imaging.