Nicky R. Faber

The paper investigates how modifying Cas9 regulatory elements affects gene drive performance in Drosophila, finding that promoter truncation reduces resistance allele formation but decreases germline cutting efficiency.

This study tests a homing gene drive in Drosophila melanogaster and finds that while simple resistance alleles can emerge, complex resistance is unlikely due to no heritable genetic effects on drive efficiency.

This paper introduces a two-target gene drive design that improves suppression efficiency by combining homing and fitness cost elements, showing success in Drosophila but highlighting remaining challenges.

This study models the potential of gene drives to suppress invasive social wasp populations and finds that only fertility-targeting drives could be effective under specific conditions.

This study investigates the feasibility of using gene drive technology to control Varroa destructor mites, finding that fertility-targeting drives fail to spread but toxin or resistance-removing drives may be viable.

This paper introduces HD-ClvR, a CRISPR-based gene drive system that eliminates resistance and localizes spread, demonstrating its effectiveness in controlling grey squirrel populations.