This study uses complete genomes to model gut microbiome metabolic interactions, revealing ecological group dynamics linked to inflammatory bowel disease and improving disease diagnosis.

Cell Reports · Aug 27, 2026Peer-reviewedMicrobiology

Comprehensive Complete-Genome Analysis of Lactobacillaceae and Bifidobacteriaceae Reveals Strain-Specific Metabolic Interactions in Chinese Gut Microbiota

Xin Tong, Hewei Liang, Yu Tian, Xinyu Yang, Ya Wang, Haoyu Wang, Yuzheng Gu, Zhihui Ma, Wenrui Su, Yanhong Liu, Sihang Cai, Zhiyin Lin, Peilin Zhang, Haifeng Zhang, Liang Xiao, , Yuanqiang Zou

The paper analyzes complete genomes of Lactobacillaceae and Bifidobacteriaceae strains to reveal strain-specific metabolic interactions in the Chinese gut microbiota.

bioRxiv · May 22, 2026 · PreprintMicrobiology

Complete Genomes of Cultivated Gut Bacteria Reveal Mobile Genetic Element-Driven Functional Diversity with Therapeutic Implications

Hao Wang, Yuzheng Gu, Wenxin He, Jinlong Yang, Hewei Liang, Mengmeng Wang, Zhinan Wu, Yangfeng Wen, Jinhong Wang, Xing Rao, Yaqi Fan, Jiayi Ma, Xinyu Yang, Xin Tong, Liye Yang, , Yuanqiang Zou

The paper presents a comprehensive compendium of fully circularized human gut bacterial genomes and reveals how mobile genetic elements drive functional diversity with therapeutic implications.

bioRxiv · Mar 25, 2026 · PreprintMicrobiology

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

Leying Zou, Zhe Zhang, Junhong Chen, Ruijin Guo, Xin Tong, Yanmei Ju, Haorong Lu, Huanming Yang, Jian Wang, Yang Zong, Xun Xu, Xin Jin, Liang Xiao, Huijue Jia, Tao Zhang, Xiaomin Liu

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

mBio · Nov 8, 2024Peer-reviewedMicrobiology

Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

Xiaomin Liu, Xin Tong, Yuanqiang Zou, Xiaoqian Lin, Hui Zhao, Liu Tian, Zhuye Jie, Qi Wang, Zhe Zhang, Haorong Lu, Liang Xiao, Xuemei Qiu, Jin Zi, Rong Wang, Xun Xu, , Tao Zhang

This study uses Mendelian randomization to identify causal relationships between gut microbiome composition and blood metabolites in a Chinese cohort.

Nature Genetics · Jan 1, 2022Peer-reviewedGenetics

Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

Xiaomin Liu, Xin Tong, Jie Zhu, Liu Tian, Zhuye Jie, Yuanqiang Zou, Xiaoqian Lin, Hewei Liang, Wenxi Li, Yanmei Ju, Youwen Qin, Leying Zou, Haorong Lu, Shida Zhu, Xin Jin, , Tao Zhang

This study identifies genetic loci associated with the oral microbiome using metagenome-genome-wide association studies in over 1,915 individuals.

Cell Discovery · Dec 6, 2021Peer-reviewedGenetics

M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases

Xiaomin Liu, Shanmei Tang, Huanzi Zhong, Xin Tong, Zhuye Jie, Qiuxia Ding, Dan Wang, Ruidong Guo, Liang Xiao, Xun Xu, Huanming Yang, Jian Wang, Yang Zong, Weibin Liu, Xiao Liu, , Tao Zhang

This paper performs M-GWAS on a Chinese cohort to identify genetic contributions to the gut microbiome and its associations with complex diseases.

Cell Discovery · Feb 9, 2021Peer-reviewedGenetics

Initial Whole Genome Sequencing and Analysis of the Host Genetic Contribution to COVID-19 Severity and Susceptibility

Fang Wang, Shujia Huang, Rongsui Gao, Yuwen Zhou, Changxiang Lai, Zhichao Li, Wenjie Xian, Xiaobo Qian, Zhiyu Li, Yu‐Shan Huang, Qiyuan Tang, Panhong Liu, Ruikun Chen, Rong Liu, Xuan Li, , Lei Liu

This study analyzes whole-genome sequencing data from 332 Chinese COVID-19 patients to identify genetic variants associated with disease severity and susceptibility.

Cell Discovery · Nov 10, 2020Peer-reviewedGenetic & Genomic Medicine