Lucia Y. Du

The paper introduces a whole-embryo spatial transcriptomics method and generates a comprehensive gene expression and chromatin accessibility atlas in zebrafish embryos.

This study creates a single-cell multi-omics atlas of zebrafish embryogenesis and identifies transcription factors that drive cell-type-specific chromatin landscapes and instant differentiation.

The paper reconstructs gene modules during cellular differentiation in zebrafish secretory tissues, identifying key transcription factors that regulate general and specialized secretion programs.

This study provides the first single-cell RNA-seq time course of zebrafish brain development, revealing the emergence of neuronal diversity and distinct neurogenic regulatory patterns across developmental stages.