Alexander F. Schier

The paper identifies transcriptional domains in the zebrafish olfactory bulb that correlate with odor preference and shows specific neuronal subtypes are recruited based on odor preference.

ITEC reconstructs high-fidelity cell lineages and fate maps of embryos with over 99.7% accuracy using iterative tracking and error correction.

The paper introduces a whole-embryo spatial transcriptomics method and generates a comprehensive gene expression and chromatin accessibility atlas in zebrafish embryos.

This study shows that temporal niche partitioning, through distinct activity patterns, contributed to the adaptive radiation of cichlid fishes in Lake Tanganyika.

This study develops optogenetic tools to control Nodal signaling patterns in zebrafish embryos, enabling precise spatial manipulation of signaling activity and rescue of developmental defects.

This study uses MPRA and polysome profiling to analyze 5' UTR regulatory features in zebrafish embryos, identifying motifs and factors influencing ribosome recruitment and translation dynamics.

This study identifies DEGT-1 as a mechanosensory ion channel in C. elegans that modulates pharyngeal pumping by detecting proprioceptive feedback from organ movement.

This study creates a single-cell multi-omics atlas of zebrafish embryogenesis and identifies transcription factors that drive cell-type-specific chromatin landscapes and instant differentiation.

The paper shows that Nodal coordinates morphogenesis in annual killifish by enabling cell migration, while Huluwa-mediated prepatterning is not required.

12.4 million single-nucleus transcriptomes from 83 staged mouse embryos (E8 to P0) yield 190 cell types, a zygote-to-pup cell-type tree, and rapid postnatal transcriptional shifts.

The paper reconstructs gene modules during cellular differentiation in zebrafish secretory tissues, identifying key transcription factors that regulate general and specialized secretion programs.

This study identifies molecular mechanisms and motifs governing Vg1 biogenesis and introduces a Synthetic Processing system for programmed protein cleavage.

The paper shows that Nodal morphogen signaling patterns in zebrafish embryos are shaped by co-receptor Oep, which restricts ligand spread and sensitizes cells.

This study provides the first single-cell RNA-seq time course of zebrafish brain development, revealing the emergence of neuronal diversity and distinct neurogenic regulatory patterns across developmental stages.

The paper uses calcium imaging in larval zebrafish to show cerebellar activity predicts motor decision timing and outcome before movement.

This study shows that zebrafish dscaml1 is crucial for retinal patterning and oculomotor circuit function, with mutations causing deficits in gaze stabilization and saccade fatigue similar to human ocular motor apraxia.

This study shows that visual habituation in larval zebrafish involves multiple independent processes that adapt different behavioural components, suggesting distributed plasticity rather than a single site of change.

This study shows that most zebrafish lncRNAs are not essential for embryogenesis, viability, or fertility, with only a few exceptions.

The paper introduces scGESTALT, a method that combines single-cell RNA sequencing with lineage tracking to identify cell types and their developmental relationships in the zebrafish brain.

The paper develops a dynamic circuit model to explain how heat sensation is transformed into swimming behavior in larval zebrafish.

This paper shows that artificial and biological neural networks converge on similar temperature representations and uses an ANN to discover a new temperature-responsive cell type in zebrafish.

The paper mutates zebrafish orthologues of schizophrenia-associated genes to identify phenotypic candidates and shared functions.

The study shows zebrafish Nanog is essential for extraembryonic tissue development but not directly required for embryonic cell differentiation.

The paper identifies asymmetric projections of central vestibular neurons in zebrafish and shows how these projections enhance sensory encoding of nose-up stimuli while maintaining gaze stabilization.

The paper presents whole-brain serial-section electron microscopy data of a larval zebrafish, enabling reconstruction of neuronal processes and analysis of axonal symmetry and connectivity.